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KMID : 0369820130430010001
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Jorunal of Korean Pharmaceutical Sciences
2013 Volume.43 No. 1 p.1 ~ p.26
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Nanosuspensions: a new approach for organ and cellular targeting in infectious diseases
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Ranjita Shegokar
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Abstract
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Most of the infectious diseases depending upon the stage of infection need treatment at least for a month to several years e.g. tuberculosis, acquired immunodeficiency syndrome. Medication by oral administration is of choice in all treatments, but unfortunately use of large doses resulting from drug poor solubility and bioavailability leads to toxicity. The problem of solubility should be solved in easiest way to reduce dose and to increase bioavailability thereby decreasing the unnecessary exposure of other organs than the targeted one without increasing the cost of treatment. Nanosuspensions offer a simple, easy and cost effective solution to solve all above issues, without exposing body to extra drug dose. They can also serve as industrially relevant formulation approach by overcoming problems associated with other drug delivery systems like low entrapment, polymer toxicity, biocompatibility and stability issues. In this paper, applications of nanosuspensions are discussed in detail focusing particularly treatment of infectious diseases. Furthermore, potential of them in targeting at organ, cellular and subcellular levels is debated.
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KEYWORD
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Poor solubility, Nanosuspensions, Bioavailability, Infectious diseases, Cellular and organ targeting, Intracellular drug delivery
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